Abstract: To evaluate the pollution statue and health risk of heavy metal in nekton of South China Sea, 11 species were collected from June to July 2019. The concentration of copper (Cu), zinc (Zn), lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As) and mercury (Hg) were measured. The results showed that the contents of 7 heavy metals met the applicable national standards. Using single factor index, a descending order of heavy metal levels showed as Zn>Cr>As>Hg>Pb>Cd>Cu, and some species were moderately polluted. Both the metal pollution index and Nemerow multi-factor index indicated all the organisms were in pollution-free states. Low risk of dietary exposure, little or none carcinogenic and noncarcinogenic risk indicated acceptable consumption of nekton in South China Sea.