Abstract: With iminodiacetic acid type chelating resin as filler, a method for the determination of twenty-two trace metal elements in seawater by inductively coupled plasma mass spectrometry (ICP-MS) after solid phase extraction separation and preconcentration was established. Adjusting the pH value of seawater to 8.5-9.0, 15% nitric acid was used as the elution solution to extract. Twenty-two trace elements in seawater were extracted and enriched. The elution solution was quantitatively analyzed using ICP-MS. The result of experiment show that: Under optimized experimental conditions, the relative standard deviation (RSD) of the method was 2.5%-4.8%, and the detection limit was 0.008-0.052 μg/L, lower limit of measurement was 0.032-0.208 μg/L, Adding standard solution of different concentrations, the recovery rates were 80.0%-108.0%. The established method was easy to operate, sensitive and efficient, achieving green separation and rapid detection of twenty-two elements in seawater. It provided technical support for marine chemistry and marine environmental research.