环境浓度下甲氧苄啶对海洋微藻生长及生化组分的影响

Effects of environmental concentrations of trimethoprim on the growth and biochemical components of marine microalgae

  • 摘要: 为了解环境浓度甲氧苄啶(trimethoprim,TMP)对海洋微藻的毒性效应,本文探究了TMP对中肋骨条藻(Skeletonema costatum)和三角褐指藻(Phaeodactylum tricornutum)生长及其生化组分的影响。结果表明,TMP对三角褐指藻的生长具有一定的促进作用,尤其是TMP为150 ng/L时,对其促进效果最为显著,藻细胞密度的最大增幅达到65%。TMP对中肋骨条藻生长的影响呈现“毒物兴奋效应(hormesis)”。在暴露前期,TMP会显著促进三角褐指藻光合色素的合成;但随着暴露时间的延长,TMP可显著抑制其光合色素合成。此外,TMP对三角褐指藻总蛋白的合成也有一定的促进作用。暴露前期,TMP对三角褐指藻的总脂合成有一定的促进作用;随着暴露时间的延长,总碳水化合物和总脂含量的变化均呈现先抑制后促进趋势。总体而言,与三角褐指藻相比,中肋骨条藻对TMP更加敏感。

     

    Abstract: To understand the toxic effects of environmental concentrations of trimethoprim (TMP) on marine microalgae, the effects of TMP on the growth and bioactive components of Skeletonema costatum and Phaeodactylum tricornutum were explored. The findings revealed that TMP had a stimulating effect on the growth of P. tricornutum, among which the 150 ng/L TMP treatment group had the most significant promotion effect, resulting in a maximum 65% increase in cell density. When TMP concentration was below, it promoted the growth of S. costatum to a certain extent; however, as concentration increased, an inhibitory effect was observed (i.e., hormesis). TMP could significantly promoted the synthesis of photosynthetic pigments in P. tricornutum during the early exposure stages, but as exposure time extended, it significantly inhibited pigment synthesis. Furthermore, TMP partially stimulated the synthesis of total protein in P. tricornutum and promoted total lipid synthesis in P. tricornutum at the early stage of exposure. The total carbohydrate and total lipid levels had a similar trend over time, initially being inhibited and subsequently enhanced. Overall, S. costatum displayed greater sensitivity to TMP compared to P. tricornutum.

     

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