Abstract: A technique for selective removal of atrazine (ATR) residues in aquaculture aqueous environment based on molecularly imprinted nanostructured polymers (MIPs) was established. Under the optimal molar ratio of template molecules, functional monomers and crosslinkers, MIPs were synthesized by precipitation polymerization with ATR as template molecule, methacrylic acid (MAA) as functional monomer, ethylene dimethacrylate (EGDMA) as cross-linking agent. Furthermore, the surface morphology, structure composition and adsorption properties of MIPs were characterized by scanning electron microscopy, fourier transform infrared spectroscopy and adsorption experiments. The effects of pH, ion concentration and humic acid (HA) on the adsorption performance of MIPs were also investigated. The results demonstrated that the prepared MIPs exhibited a regular microspherical structure and good imprinting recognition capability. When pH 6.0, NaCl 4.0% and humic acid (HA) content 10.0%, the maximum adsorption capacity of the developed MIPs was 14.80 mg/g, and the adsorption equilibrium time was less than 30 min. The developed MIPs by this method could be used for the rapid and highly efficient removal of ATR residues in aqueous environment.