Abstract: Based on the driven wind incorporating the Cross Calibrated Multi-Platform remotely sensed wind and Holland typhoon model, nested typhoon wave model is developed by SWAN to simulate the waves caused by "MUIFA".After obtaining the incorporation way, 9 schemes in wind establishment, 3 calibration coefficient schemes and 3 weighting coefficient schemes are employed, then they are conducted to the wave simulation in East China Sea and the results are compared with the significant wave height of Jason-1 altimeter.The results show that the relative error of significant wave height can have a difference of 3%.Choose the result of the best scheme to provide wave spectrum boundary condition for the nested domain and the results demonstrate that the computation results fit the buoy data well, the wave height in Jiangsu coastal area can reach 5~6 m, the northern and central Jiangsu coastal areas are dominated by swell whereas the southern areas are greatly affected by wind wave during typhoon "MUIFA".