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Volume 34 Issue 4
Jul.  2015
Article Contents

Citation:

Effects of DEHP on embryonic development and DNA damage of Pinctada maetensii

  • Received Date: 2014-03-04
    Accepted Date: 2014-05-14
  • Di-2-ethylhexyl phthalate (DEHP) is used as a plasticizer commonly and exists widely in environment.The effects of early D-shaped veliger larvae development and embryonic DNA damage of Pinctada martensii exposure to DEHP were studied in this report.The results showed that DEHP had a significant effect on the development of D-shaped veliger larvae.There was a positive correlation between mortality rate of D-shaped veliger larvae and exposure time of DEHP in a same concentration group.In the concentration groups of (4~32 )mg/L,there was a significant dose-response relationship between the larval mortality rate and exposure concentrations at different exposure time.It can be concluded that DEHP exposure caused adverse effects on the development of D-shaped veliger larvae and may also influence the population structure of Pinctada martensii.DEHP exposure induced DNA damage of embryo cells significantly.There was a good dose-effect relationship between DNA migration and DEHP concentrations.Tail length (TL),tail DNA content (T-DNA) and olive tail moment (OTM) increased significantly with exposure concentration.The results indicated that developmental and morphological changes of D-shaped veliger larvae and the DNA damages in embryo cells of Pinctada martensii could be used as sensitive biomarkers of DEHP exposure in the marine environment.
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  • [1] 李海涛,黄岁樑.水环境中邻苯二甲酸酯的迁移转化研究[J].环境污染与防治,2006,28(11):852-858.[3]庄婉娥,姚文松,汪厦霞,等.泉州湾海水及沉积物中邻苯二甲酸酯的分布及化学组成[J].环境与健康杂志,2011,28(10):898-902.[4]李 潇,聂湘平,潘德博,等.养殖鱼体邻苯二甲酸酯含量与分布特征[J].环境与健康杂志,2008,25(3):202-205.[5]柯翔鸿,王黎明,李 艳,等.DEHP对小鼠脑细胞DNA的影响及组织器官氧化损伤[J].医学研究杂志,2008,36(6):27-31.[6]蔡文贵,秦洁芳,贾晓平,等.邻苯二甲酸单二乙基己酯对翡翠贻贝(Perna viridis)生化指标的影响[J].生态学杂志,2012,31(1):100-105.[7]秦洁芳,陈海刚,蔡文贵,等.邻苯二甲酸二乙基己酯(DEHP)胁迫下红鳍笛鲷不同组织生化指标的变化[J].农业环境科学学报,2001,30(3):409-415.[8]张蕴晖.邻苯二甲酸酯类的雄性生殖发育毒性及健康危险度评价[D].上海:复旦大学,2004.[11]周海龙,曲 莹,董 方,等.持久性有机污染物的海洋动物胚胎毒理学研究进展[J].海洋科学,2010,34(1):84-89.[15]金启增,魏贻尧,郭澄联,等.珍珠贝种苗生物学[M].北京:海洋出版社,1992:50.[17]王 蕊,李厚勇,王子兰,等.邻苯二甲酸(2-乙基己基)酯致畸致突变实验研究[J].癌变 畸变 突变,2002,14(2):120-121.[18]李 潇.邻苯二甲酸酯类在养殖鱼类体内含量分析及其胚胎毒性研究[D].广州:暨南大学,2007.[19]谢 嘉,刁晓平,杨 宝,等.芘污染对马氏珠母贝(Pinctada martensi)D型面盘幼虫发育的影响[J].生态毒理学报,2013,8(3):366-373.[21]GILBERT S F,EPEL D.Ecological developmental biology[M].Sunderland:Sinauer Associates,2008:122-134.[22]张先勇,刁晓平,杨 宝,等.苯并[a]芘对马氏珠母贝血淋巴细胞DNA损伤的研究[J].生态环境学报,2011,20(6/7):1107-1110.[24]赵文红,厉曙光,石红军.单细胞凝胶电泳检测酞酸酯类对DNA的损伤[J].中国公共卫生,2004,20(10):1164-1165.[25]陈 莉,李学彬,杨光涛,等.邻苯二甲酸二乙基己酯(DEHP)对金鲫鱼脑细胞DNA的损伤[J].生态毒理学报,2008,3(2):144-148.
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Effects of DEHP on embryonic development and DNA damage of Pinctada maetensii

  • 1. College of Agriculture, Hainan University, Haikou 570228, China;
  • 2. College of Environment and Plant Protection, Hainan University, Haikou 570228, China;
  • 3. Haikou Key Laboratory of Environment Toxicology, Hainan University, Haikou 570228, China

Abstract: Di-2-ethylhexyl phthalate (DEHP) is used as a plasticizer commonly and exists widely in environment.The effects of early D-shaped veliger larvae development and embryonic DNA damage of Pinctada martensii exposure to DEHP were studied in this report.The results showed that DEHP had a significant effect on the development of D-shaped veliger larvae.There was a positive correlation between mortality rate of D-shaped veliger larvae and exposure time of DEHP in a same concentration group.In the concentration groups of (4~32 )mg/L,there was a significant dose-response relationship between the larval mortality rate and exposure concentrations at different exposure time.It can be concluded that DEHP exposure caused adverse effects on the development of D-shaped veliger larvae and may also influence the population structure of Pinctada martensii.DEHP exposure induced DNA damage of embryo cells significantly.There was a good dose-effect relationship between DNA migration and DEHP concentrations.Tail length (TL),tail DNA content (T-DNA) and olive tail moment (OTM) increased significantly with exposure concentration.The results indicated that developmental and morphological changes of D-shaped veliger larvae and the DNA damages in embryo cells of Pinctada martensii could be used as sensitive biomarkers of DEHP exposure in the marine environment.

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